EPA competes with arachidonic acid (AA) for the LOX (Lipoxygenase) and COX (Cyclooxygenase) pathways. EPA vs. AA: The Battle for Inflammation Control
Imagine your body as a busy highway system, where different types of cars compete for limited toll booths (LOX and COX enzymes) to pass through. These toll booths control traffic flow, determining whether the road stays clear or gets congested with roadblocks (inflammation).
Two Types of Cars on the Highway:
Arachidonic Acid (AA) Cars
These cars are aggressive drivers. When they reach the toll booths, they trigger traffic jams (inflammation) by producing Pro-inflammatory prostaglandins, thromboxanes, and leukotrienes. These signals can lead to swelling, pain, and clot formation—things that cause chronic inflammation in the body.
EPA (Omega-3) Cars
These cars are smoother, more efficient drivers. They compete for the same toll booths as AA cars, but instead of causing congestion, they produce less inflammatory or even anti-inflammatory signals, keeping traffic flowing smoothly.
What Happens When EPA Takes Over the Toll Booths?
Since the number of LOX and COX enzymes (toll booths) is limited, EPA cars crowd out AA cars, meaning fewer inflammatory roadblocks (inflammation) are created.
The AA cars that can’t get through don’t just disappear—they have three possible fates:
- Stored for Later Use – They are parked in cell membranes, waiting for another chance to be used when toll booths open up.
- Forced to Take a Different Route – AA may be converted into other, less harmful molecules.
- Gradually Replaced Over Time – If you CONSISTENTLY consume EPA, your body slowly reduces its AA reserves, shifting toward a more balanced, anti-inflammatory state.
By increasing your EPA intake through omega-3 supplements or fatty fish, you’re essentially changing the traffic system in your body—reducing the risk of chronic inflammation, improving heart health, supporting joint function, and promoting overall well-being.
In simple terms: More EPA means fewer inflammation-causing roadblocks, leading to a healthier, smoother-running body.
We’ve established that EPA competes with Arachidonic Acid (AA) for LOX and COX enzymes, just like calm, efficient drivers (EPA) vs. aggressive traffic-jamming cars (AA). Phatma® 1440 Golden Bottle is engineered with a 5:1 EPA: DHA ratio—an optimized formulation to ensure maximum traffic control against inflammation.
Maximizing EPA’s Competitive Advantage Against AA
A 5:1 EPA: DHA ratio ensures a high EPA load to outcompete AA for LOX and COX enzymes. This means fewer inflammatory molecules (PGE2, TXA2, LTB4) are produced, leading to reduced swelling, pain, and clot formation. Higher EPA levels = fewer inflammatory roadblocks = smoother body function.
Efficiently Reducing AA Reserves Over
Consistently consuming Phatma® 1440 helps gradually replace stored AA. Over time, this shifts your body’s balance toward an anti-inflammatory state, preventing chronic diseases.
Supports Joint & Cardiovascular Health by Controlling Inflammation
Excessive AA activity contributes to arthritis, cardiovascular disease, and metabolic dysfunction. Phatma® 1440’s high EPA content actively counters these risks, helping maintain joint mobility and heart function.
More EPA Without Excess DHA for Targeted Effects
DHA plays a crucial role in brain and eye health, but in inflammation control, EPA is the key player. A 5:1 ratio prioritizes EPA for inflammation reduction while still providing enough DHA to support neuroprotection. Perfect for athletes, professionals, and individuals needing precise inflammation management.
